UK Critical Care Genomics (UKCCG) group



Aims of the Group.

To undertake clinical functional genomics research in the critically ill and to develop related collaborative, laboratory based research projects with scientific colleagues.

To disseminate knowledge and promote understanding of functional genomics in the wider intensive care community.

To develop collaborations with colleagues outside the UK, with the particular objective of recruiting larger patient cohorts to achieve increased power and to allow replication.

Access the GAinS sample archive

We would like to encourage investigators in the field of Critical Care Medicine in the UK to apply to the GAinS management committee for access to the archive, for scientifically sound projects. Investigators should initially submit a short outline of their proposed research to the committee and may be invited to subsequently submit a more detailed plan of investigation.

Key Publications

Brendon et al. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study . Lancet Respiratory Medicine 2017.
Burnham et al Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. American Journal of Respiratory and Critical Care Medicine 2017; 196: 328-339
Dalli et al. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med. Dec 2013.
Dalli et al. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics. Aug2013
Davenport et al. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med. 2016 Apr;4(4):259-71
Eisen et al. Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis. Aug 2008.
Fairfax BP et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nature Genetics 44 2012.
Fairfax BP et al An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. Hum Mol Genetics 2010
Fragkou PC et al.Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Critical Care 2014.
Garrard CS, Hinds C, Knight JC. Applications in critical care medicine. In: Kumar D, Weatherell D (eds) Genomics and Clinical Medicine 2007, Oxford University Press
Gordon AC, Knight J, Hinds CJ. (Editorial) Genes and sepsis: How tight is the fit? Crit Care Med 2008.
Gordon et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock. Jan 2006.
Gordon et al. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun. Dec 2004.
Maugeri N et al Genetic determinants of HSP70 gene expression following heat shock. Hum Mol Genetics 2010.
Mills TC et al. IFITM3 and susceptibility to respiratory viral infections in the community. J Infect Dis. Aug 2013
Mills TC et al. Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort. Clinical Infectious Diseases 2015 Sep 1;61(5):695-703
Owen HC et al. Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. J Trauma Acute Care Surgery 2015; 79: 766-772.
Rauntanen A et al.Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med. 3: 53 - 60. Jan 2015
Russell et al. Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis. Annals of Intensive Care 2017 (in press)
Scherag et al Genetic factors of the disease course after sepsis: A genome-wide study for 28 day mortality. EBioMedicine 2016
Torrance HD et al. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured Polytrauma Patients. Annals of Surgery 2014.
Torrance HD et al. Changes in gene expression following trauma are related to the age of transfused packed red blood cells. Journal of Trauma and Acute Care Surgery 2015; 78: 535-542.
Tridente A et al. Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Intensive Care Med. Dec 2013.
Tridente et al. Derivation and validation of a prognostic model for post-operative risk stratification of critically ill patients with faecal peritonitis. Annals of Intensive Care. 2017 7:96
Tridente A et al Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort. Crit Care. 19(1): 210. 2015.
Walden AP et al. Patients with community acquired pneumonia admitted to European Intensive Care Units: an epidemiological survey of the GenOSept cohort. Critical Care 2014

MEMBERSHIP OF THE UKCCG

Affliated organisations